SILAB’s PEPTILIUM targets the three compartments of the skin

A targeted transcriptomic analysis performed by SILAB has also shown that, out of 34 genes involved in skin homeostasis, 76% are deregulated during aging. Thanks to SILAB’s PEPTILIUM, the expression of 81% of these deregulated genes is normalised.

Composed of natural biopeptides purified to 95%, obtained from the co-product of a superfruit, the cranberry, PEPTILIUM is a global anti-aging active ingredient. Sustainable and effective, it boosts complexion radiance and attenuates fine lines and wrinkles.

Transversal biological activity

Due to their richness and their molecular diversity, the natural biopeptides that make up PEPTILIUM have the ability to act transversally on several biological targets. The active ingredient thus acts on the various skin compartments:

– it reinforces the epidermal barrier function and boosts complexion radiance [1];

– it improves the quality of the dermal-epidermal junction and of the dermal matrix for an anti-wrinkle action [2].

Rapid and global anti-ageing action

As of 21 days of application, PEPTILIUM tested at 2% in an emulsion significantly improves the parameters characteristic of complexion radiance in Caucasian (reflection: +12%; pink colour: +17%) and Asian subjects (luminosity: +6%; olive colour: -5%).

In the same conditions, PEPTILIUM presents an anti-wrinkle effect in Caucasian (negative volume: -22%) and Asian (stage of crow’s feet wrinkles: -10%) volunteers. These radiance boosting and anti-wrinkle effects intensify after 42 days of treatment and are confirmed by a subjective evaluation: 100% of Caucasian and Asian volunteers consider in particular their fine lines and wrinkles to be attenuated.

A comparative study conducted by SILAB also demonstrates that the efficacy of PEPTILIUM is more intense and more rapid than that of retinol, while having no side effect.

The local agent for SILAB is Meganede.

An upcycling approach

SILAB got interested in a superfruit, the cranberry (Vaccinium macrocarpon). Used by Native Americans in traditional medicine, this small red fruit from North America is today considered to be a health food throughout the world.

In an upcycling approach, SILAB has specifically selected one of its co-products, the cranberry fruit press cake, in particular for its high molecular potential. The company prioritised a supplier committed to practices of sustainable development and implemented internally a specific eco-extraction process to produce the natural biopeptides purified to 95%.

PEPTILIUM (Vaccinium macrocarpon (Cranberry) Fruit Extract) is a patented product, available in aqueous solution (recommended amount: 0.5 to 2%). This active ingredient has a content of natural origin of 99% (ISO 16128) and is compliant with international cosmetic regulations (Europe, United States, China, Japan, etc.).

[1] Tested at 0.5% on aged SILABSKIN® RE reconstructed epidermis, PEPTILIUM® significantly restores keratinocyte proliferation (synthesis of Ki-67: +86%) and differentiation (synthesis of loricrin: +49%), two processes indispensable for renewal of the barrier function.

[2] Tested at 0.1% on aged fibroblasts, PEPTILIUM® significantly increases the production of the collagen I network by 54% and therefore maintains matrix fibers functionally organized.